Pregled bibliografske jedinice broj: 228180
Piroxicam-cyclodextrin-hydroxypropyl methylcellulose multicomponent systems
Piroxicam-cyclodextrin-hydroxypropyl methylcellulose multicomponent systems // Proceedings of 12th International cyclodextrin Symposium / Duchene, Dominique ; Fattal, Elias (ur.).
Châtenay-Malabry: Association de Pharmacie Galenique Industrielle, 2004. str. 823-826 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
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Naslov
Piroxicam-cyclodextrin-hydroxypropyl methylcellulose multicomponent systems
Autori
Jug, Mario ; Bećirević-Laćan, Mira
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Proceedings of 12th International cyclodextrin Symposium
/ Duchene, Dominique ; Fattal, Elias - Châtenay-Malabry : Association de Pharmacie Galenique Industrielle, 2004, 823-826
Skup
12th International cyclodextrin Symposium
Mjesto i datum
Montpellier, Francuska, 16.05.2004. - 19.05.2004
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
piroxicam; cyclodextrin; multicomponent systems
(piroksikam; ciklodekstrini; multikomponentni sustavi)
Sažetak
Multicomponent systems containing piroxicam, ß-cyclodextrin and dimethyl-ß-cyclodextrinin the presence of hydroxypropylmethyl cellulose in aqueous solution and in the solid state were prepared and characterised. The use of polymer-cyclodextrin-drug multicomponent systems in drug delivery offers some benefits. In solution, HPMC increased the complexation efficiency of CD by forming ternary complexes with higher stability constants compared to binary. In solid state, multicomponent systems offered fine balance between improved drug solubility and controlled drug delivery.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Farmacija
