Naslov
Posttransplant lymphoproliferative disorder. A case report

Autori
Fabijanić, I ; Kardum-Skelin, Ika ; Šušterčić, Dunja ; Cvrlje-Čolić, Vesna ; Naumovski-Mihalić, Slavica ; Škegro, Dinko ; Šiftar, Z ; Kušec, Rajo ; Anić, P. ; Jakšić, Branimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka 3. Hrvatskog kongresa patologije i sudse medicine.3. Hrvatski kongres kliničke citologije. 1. Hrvatski simpozij citotehnologije / Jonjić, Nives ; Kardum-skelin, Ika - Karlovac, 2005

Skup
3. Hrvatskog kongresa patologije i sudse medicine.3. Hrvatski kongres kliničke citologije. 1. Hrvatski simpozij citotehnologije

Mjesto i datum
Opatija, Hrvatska, 08.05.2005. - 11.05.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PTLD; transplantacija
(PTLD; transplantation)

Sažetak
Introduction: Posttransplant lymphoproliferative disorders (PTLD) represent an immunophenotypic, genotypic, and clinical spectrum of diseases seen in patients after bone marrow and solid-organ transplantation (SOT). PTLD are mostly of B-cell origin and are associated with Epstein-Barr virus (EBV). The incidence of PTLD is 2-10% in liver transplant recipients, ranging from 2 to 3 % in adults to more than 10% in some pediatric series. Patient: A 50-year old man with an antecedent history of type 2 diabetes mellitus underwent an orthotopic liver transplantation (OLT) due to HCV-related end-stage liver disease. Immunosuppressive treatment included cyclosporine and prednisone. Three months after transplant, the patient had jaundice with elevated liver function tests. Color Doppler sonography (US) and computerized tomography (CT) scans showed abdominal lymphadenopathy. US-guided fine needle aspiration biopsy (FNAB) revealed non Hodgkin’ s large cell lymphoma. Flow cytometry showed these cells to be a monoclonal B-cell population, and a diagnosis of monomorphous/diffuse large B-cell lymphoma (DLBCL) was made. Furthermore, analysis of immunoglobulin heavy– chain gene using polymerase chain reaction (PCR) on cytological samples confirmed a monoclonal population of B-cell lineage. A bone marrow biopsy was negative for lymphoproliferative disorder. All investigations for EBV including immunocytochemical studies on cytological smears, serological tests and PCR were negative. Moreover, cytomegalovirus (CMV) DNA in peripheral blood by PCR showed an insignificant number of copies. Conclusions: PTLD is a significant and growing problem, due to increase in the number of SOT recipients. Considering the prognosis of PTLD, an early diagnosis and monitoring of transplant recipients will help to identify patients who could benefit from preemptive therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA