Pregled bibliografske jedinice broj: 226662
Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy
Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy // Periodicum Biologorum, vol 106, Supp 1
Zagreb, 2004. (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 226662 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy
Autori
Markotić, Anita ; Čikeš Čulić, Vedrana ; Tičinović Kurir, Tina ; Radić, Saša ; Zemunik, Tatijana ; Mesarić, Marko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Periodicum Biologorum, vol 106, Supp 1
/ - Zagreb, 2004
Skup
Fourth Croatian Congress of Pharmacology
Mjesto i datum
Split, Hrvatska, 14.09.2004. - 18.09.2004
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
gangliosides; hyperbaric oxygenation; immunostaining; partial hepatectomy
Sažetak
Introduction: Remnant liver after partial hepatectomy (PH) demands an increased amount of oxygen to restore hepatic energy. Modulation of the ganglioside content of hepatocyte plasma membrane could provide a mean for upregulating cellular responsiveness to a variety of factors. Materials and Methods: Rat liver gangliosides were analysed by high perfomance thin layer chromatography (HPTLC) followed with immunostaining 54 h after PH. Non-operated and three different groups of operated rats were studied according to the hausing conditions before or after operation: recovering under normal ambient conditions after operation (1), treating with hyperbaric pressure before operation and recovering under normal ambient conditions (2 or preHB), and recovering under hyperbaric pressure after operation (3 or postHB). Results: Liver of preHB group showed the highest expression of ganglioside GD1a, a marker of a peculiar transition phase of liver regeneration. Same animals showed enhanced expression of the several gangliosides: GM2, GM1a, GD1b, GT1b, GalNAcGM1b, nLc4, nLc6 and nLc8. Conclusion: Since galactosyl- and N-acetylgalactosaminyltransferase catalyse final step of synthesys of GM2, GM1a, GD1b, GalNAcGM1b, nLc4, nLc6, and nLc8, our results point at possible role of galactosyl- and N-acetylgalactosaminyltransferase in regulation of the liver growth after PH.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Temeljne medicinske znanosti
