Naslov
Changes in T-cell subpopulations during 4 years of suppression of HIV-1 replication in patients with advanced disease

Autori
Židovec Lepej, Snježana ; Begovac, Josip ; Vince, Adriana

Izvornik
FEMS Immunology and Medical Microbiology (0928-8244) 46 (2006), 3; 351-359

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HIV; HAART; immune reconstitution; longitudinal

Sažetak
We compared the number/percentages of naive and memory CD4+ T-cells, CD38+CD8+ T-cells and CD28+CD4+ and CD28+CD8+ T-cells in patients with advanced (baseline CD4+ count < 100) with those with less advanced (baseline CD4+ cell count > 100) HIV-disease during 4 years of suppressive HAART. Advanced patients gained more naive CD4+ T-cells at 48 months. The relative gain in memory CD4+ T-cells was greater in advanced versus less advanced patients at 1 months and 48 months. At 48 months, CD38+CD8+ T-cells and naive CD4+ T-cells reached normal values in less advanced patients as well as CD38+CD8+ T-cells in advanced patients. The kinetics of truly naive and memory CD4+ T-cell reconstitution is different in less advanced compared to advanced HIV-patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA