Pregled bibliografske jedinice broj: 223046
Osteogenic protein-1 is produced by human fetal trophoblasts in vivo and regulates the synthesis of chorionic gonadotropin and progesterone by trophoblasts in vitro
Osteogenic protein-1 is produced by human fetal trophoblasts in vivo and regulates the synthesis of chorionic gonadotropin and progesterone by trophoblasts in vitro // European Journal of Clinical Chemistry and Clinical Biochemistry, 34 (1996), 2; 103-109 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 223046 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Osteogenic protein-1 is produced by human fetal trophoblasts in vivo and regulates the synthesis of chorionic gonadotropin and progesterone by trophoblasts in vitro
Autori
Martinović, Snježana ; Latin, Višnja ; Suchanek, Ernest ; Stavljenić-Rukavina, Ana ; Sampath, Kuber T. ; Vukičević, Slobodan
Izvornik
European Journal of Clinical Chemistry and Clinical Biochemistry (1434-6621) 34
(1996), 2;
103-109
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Osteogenic protein-1; Trophoblast; Chorionic gonadotropin; Progesterone
Sažetak
Osteogenic protein-1 (OP-1/BMP-7), a member of the transforming growth factor (TGF-beta) superfamily of proteins, is shown to be expressed at sites of epithelial-mesenchymal tissue interaction during human fetal development. In the present study, we examined the expression of OP-1 in human placentas (5-11 weeks of gestation and full term) using in situ hybridization and immunohistochemistry methods. The results show that OP-1 was expressed in cytotrophoblasts (Langhans' layer) of the chorionic villi in early and full term placentas. Employing highly purified cytotrophoblast cultures which fused to form functional syncytiotrophoblasts, we showed that exogenously added recombinant OP-1, in the presence of low serum concentration, reduced the secretion of chorionic gonadotropin and progesterone by 60% and 36%, respectively, compared with control cultures. The results suggest that osteogenic protein-1 is synthesized locally by cytotrophoblasts and may be involved in the regulation of human pregnancy by controlling reproductive hormonal secretion.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
301089
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Slobodan Vukičević
(autor)
Snježana Martinović
(autor)
Ernest Suchanek
(autor)
Ana Stavljenić
(autor)
Višnja Milković-Latin
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI