Naslov
Stem cell antigen 2 expression in adult and developing mice

Autori
Antica, Mariastefania ; Wu, Li ; Scollay, Roland

Izvornik
Immunology letters (0165-2478) 55 (1997), 1; 47-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
development ; sca-2/tsa-1 antigen ; stem cells ; T-lymphocytes ; precursor cells

Sažetak
Stem cell antigen 2 (Sca-2) expression can distinguish the most immature T-lymphocyte precursors in the thymus from the hemopoietic stem cells. Sequence analysis of the Sca-2 protein showed that Sca-2 is a glycosylphosphatidylinositol (GPI) anchored molecule that shares some characteristics with the members of the Ly-6 multigene family, and that it is the same as the thymic shared antigen-1 (TSA-1). Here we extend these studies and critically reassess the expression of the Sca-2/TSA-1 antigen in hematopoietic tissues of adult and developing mice. With more sensitive methods we show that the distribution of Sca-2/TSA-1 differs from existing reports. We find especially high expression of Sca-2/TSA1 at day 14 of fetal development. (C) 1997 Elsevier Science B.V. [References: 22]

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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