Pregled bibliografske jedinice broj: 220267
NK cell-dependent liver injury triggered by liver NKT cell activation
NK cell-dependent liver injury triggered by liver NKT cell activation // Annual meeting of Croatian immunological society / Jonjić, Stipan ; Dekaris, Dragan ; Polić, Bojan ; Gagro, Alenka ; Vitale, Branko ; Malenica, Branko ; Rabatić, Sabina ; Barac-latas, Vesna ; Trobonjača, Zlatko ; Božić, Frane ; Bubić, Ivan (ur.).
Rijeka: Hrvatsko imunološko društvo, 2005. str. 59-59 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 220267 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
NK cell-dependent liver injury triggered by liver NKT cell activation
Autori
Trobonjača, Zlatko ; Hlača, Tamara ; Krajina, Tamara ; Reimann, Joerg
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Annual meeting of Croatian immunological society
/ Jonjić, Stipan ; Dekaris, Dragan ; Polić, Bojan ; Gagro, Alenka ; Vitale, Branko ; Malenica, Branko ; Rabatić, Sabina ; Barac-latas, Vesna ; Trobonjača, Zlatko ; Božić, Frane ; Bubić, Ivan - Rijeka : Hrvatsko imunološko društvo, 2005, 59-59
Skup
Annual meeting of Croatian immunological society
Mjesto i datum
Božava, Hrvatska, 29.09.2005. - 02.10.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
NK cell; NKT cell; liver injury; alfa-galctosyl ceramide
Sažetak
Activation of the liver NKT cells triggered by injection of the low dose alpha-galactosylceramide ( Gal/Cer) into mice induces liver injury. This effect is suppressed in mice depleted of NK cells, therefore NK cells recruited into this response are largely responsible for NKT-cell initiated liver injury. Our in vitro results showed that liver NKT cells provide CD80/86 dependent signal to alphaGal/Cer pulsed dendritic cells to release IL12 p70. That cytokine stimulate the IFNgamma response of NKT and NK cells. Adoptive transfer of in vitro NKT cell-activated liver dendritic cells into the liver of normal B6 mice via the portal vein elicited IFN response of liver NK cells in situ. IFNgamma down regulates the IL12/IFNgamma cytokine cascade triggered by NKT cells/DC/NK cell interactions in the liver. Pretreating liver DC in vitro with IFNgamma supressed their IL12 p70 (but not IL10 ) release in response to CD40 ligation or specific interaction with liver NKT cells, and downregulated the IFN response of the specifically activated liver NKT cells. In vivo, IFNgamma attenuate the NKT cell-triggered induction of liver immunopathology. This study identifies interacting subsets of the hepatic innate immune system activated early in immune-mediated liver pathology, and cytokines involved in these interactions.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
