Naslov
Analysis of c-kit mutations in acute myeloid leukemia (AML) with t(8 ; 21)

Autori
Drmić, Irena ; Radnić, Maja ; Zadro, Renata ; Kušec, Rajko ; Grahovac, Blaženka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3. hrvatski kongres patologije i sudske medicine, 3. hrvatski kongres kliničke citologije, 1. hrvatski kongres citotehnologije s međunardnim sudjelovanjem, Knjiga sažetaka / Jonjić, Nives ; Kardum-Skelin, Ika - Zagreb : HRG, 2005, 46-46

Skup
3. hrvatski kongres patologije i sudske medicine, 3. hrvatski kongres kliničke citologije, 1. hrvatski kongres citotehnologije s međunardnim sudjelovanjem

Mjesto i datum
Opatija, Hrvatska, 08.05.2005. - 11.05.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
c-kit; acute myeloid leukemia

Sažetak
Acute myeloid leukemia (AML) has been proposed to arise from the cooperation between abnormalities in genes that incode transcription factors (TF) and tyrosine kinases (TK). Disruption of TFs is often a result of recurring chromosomal translocation with inhibition of haematopoietic differentiation, whereas the mutations in receptor TK, c-kit and other provide a proliferative signal. The most common chromosomal translocation, t(8 ; 21)(q22 ; q22), in AML generates AML1/ETO fusion gene. According to recent data, genetic abnormalities that cooperate with AML1/ETO to induce AML remain elusive, as well as clinical significance of c-kit mutations in leukemias with t(8 ; 21). To estimate the prevalence of c-kit mutations in AML, we analyzed several c-kit mutations in coding sequences and promoter region in AML1/ETO positive patients (n=25). Obtained results suggest that further studies with extended number of patients at disease presentation, during therapy and follow-up are required to evaluate significance of c-kit mutations in prognosis and therapy of AML.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA