Naslov
Genital herpes infections and vaccines

Autori
Slavica, Lucija ; Mačak Šafranko, Željka ; Brkić, Lada ; Mikloška, Zorka

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Immuno-modulatory drugs

Urednik/ci
Kniewald, Zlatko

Izdavač
Medicinska naklada ; Hrvatsko Društvo za Biotehnologiju

Grad
Zagreb

Godina
2005

Raspon stranica
61-65

ISBN
953-176-315-1

Ključne riječi
Herpes simplex virus, cytotoxic T cells, vaccine

Sažetak
Genital herpes, caused by infection with Herpes simplex virus (HSV) 2 or 1, is a important sexually transmitted disease associated with neoplasia, and is a co-factor in HIV transmission. After infection of the mucosa or skin, Herpes simplex virus type 2 or 1, is transmitted retrogradely to the neurons of dorsal root ganglia where it replicates and establishes latency. Upon appropriate stimulus, the virus is transported back to reinfect skin or mucosa in the episode of recurrent herpes. In an immunocompetent host, recurrent HSV is a self-limiting disease where cytotoxic T lymphocytes and to a weaker extent neutralizing antibodies, resolve lesion with time. The danger for horizontal spread is in prevalent asymptomatic lesions of skin/mucosa. The search for genital herpes vaccine is few decades long. The only partially successful vaccine by now, developed by GlaxoSmithKline, showed clear gender bias, being effective only in women negative for Herpes simplex type 1 and 2. It also showed the importance of previous infection with HSV-1 in prevention of HSV-2 infection. Here we discuss the immunopathogenesis of recurrent human herpes infection, history of genital vaccine development and our data concerning the development of therapeutic and prophylactic vaccine against genital herpes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA