Naslov
SERUM URIC ACID IN PREDIABETIC AND NEWLY DIAGNOSED CHILDREN WITH INSULIN DEPENDENT DIABETES MELLITUS

Autori
Ročić, Boris ; Kadrnka-Lovrenčić, Magda ; Vučić, Marijana ; Kežević-Ćuća, Jadranka ; Mesić, Ranko

Izvornik
Diabetologia Croatica (0351-0042) 27 (1998), 2; 81-84

Ključne riječi
uric acid; prediabetes; islet cell antibodies

Sažetak
Insulin dependent diabetes mellitus (IDDM) is a chronic disorder that results from autoimmune destruction of the pancreatic b -cells. An initial toxic action to the b -cells has been suggested and alloxan-like compounds derived from oxidative degradation of uric acid are plausible candidates which might initiate b -cell damage, leading to the immune system activation. Among various serologic markers associated with an ongoing process of b -cell destruction, islet cell antibodies (ICA) are the best validated marker of the risk of IDDM development in genetically susceptible individuals, particularly first-degree relatives of patients with IDDM. We investigated serum uric acid concentrations in children with newly diagnosed IDDM and both ICA-positive and ICA-negative children of first-degree relatives of IDDM patients. Uric acid was significantly elevated in ICA-positive when compared to newly diagnosed IDDM children (270ą 40 vs. 220ą 43 m mol/l, p<0.005), whereas no difference was found on comparison to ICA-negative and healthy control children or children with prolonged duration of IDDM (270ą 43 vs. 248ą 39 vs. 252ą 42 vs. 249ą 44 m mol/l, NS). These results indicate fluctuation of the uric acid level during the as yet unknown process from ICA-positive finding to manifest diabetes mellitus. Although uric acid concentration is a biochemical rather than serologic marker, its measurement is likely to be a valuable tool for understanding the mechanisms of initial b -cell lesion.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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