Naslov
Botulinum toxin type A in rat model of muscle hyperalgesia

Autori
Bach-Rojecky, Lidija ; Lacković, Zdravko ; Relja, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 16th International Congress on Parkinson's Disease and Related Disorders ; u: Parkinsonism & related disorders 11 (2005) (S2) ; Poster symposia ; PS004 Botulinum toxin 105-106 / - , 2005, 106-106

Skup
International Congress on Parkinson's Disease and Related Disorders (16 ; 2005)

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
botulinum toxin A; pain

Sažetak
Objective was to investigate the influence of botulinum toxin type A (BTX-A) on muscle hyperalgesia in rats induced with repeated intramuscular acidic saline injections. Right gastrocnemius muscle was injected twice with 100 l of pH 4 saline four days apart. Rat in one group received BTX-A ( 5 U/kg) into the plantar surface of the right hind-paws 5 days before injection, while the second group underweant the same treatment on the other side. After the second saline injection bilateral hypersensitivity (p<0.01) was observed. Pre-treatment with BTX-A prevented the development of hyperalgesia on both sides (p<0.01) only when toxin was injected into the ipsilateral hind-paws. When applied contralateraly the toxin inhibited the development of hypersensitivity on contralateral side only. These results demonstrate the effectivness of BTX-A in prevention of hyperalgesia induced by muscle injury.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Peter Franz Riederer, Susanne W. Burns, Manfred Gerlach (ur.) ; DOI: 10.1016/S1353-8020(05)80088-4 ; Riječ je o poster konferenciji na poziv, tj. o posteru i predavanju uz PP prezentaciju, odnosno o pozvanom predavanju.

POVEZANOST RADA