Naslov
Influence of methionine-enkephalin on stress-induced parameters

Autori
Šverko, Višnja ; Marotti, Tanja ; Ročić, Boris ; Rabatić, Sabina ; Hršak, Ivo

Izvornik
International journal of immunopharmacology (0192-0561) 19 (1997), 11-12; 691-698

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
stress; lipid peroxidation; corticosterone; methionine-enkephalin

Sažetak
This study examines the influence of methionine-enkephalin (MENK) on stress-induced oxidative damage (lipid peroxidation ; LPO) in mice liver homogenate, plasma corticosterone concentration (CS) and phagocytic activity of mouse splenocytes. The LPO value increased in the mice subjected to restraint stress and had no correlation to stress duration, while MENK had no effect. The CS concentration was enhanced after 6 h of stress and 6 h after injection of a low (2.5 mg/kg bw) dose of MENK. However, MENK and stress are adjunct modulators of LPO and corticosterone in vivo. LPO was additionally elevated when MENK (10 mg/kg bw) proceeded for 2 h after the onset of stress. However, corticosterone concentration seems to be regulated differently by the same dose of MENK depending on the duration of stress i.e. elevated in cases involving short periods of stress (2 h) and decreased in cases involving prolonged periods of stress (6 h). This modulation of LPO and corticosterone by 10 mg/kg bw of MENK and 2 h of restraint stress was paralleled with elevated phagocytosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA