Pregled bibliografske jedinice broj: 21424
Synthesis of sulfamethoxazole metabolites
Synthesis of sulfamethoxazole metabolites // Abstract book / Paoletti, R. (ur.).
Milano: Fondazione Giovani Lorenzini, Milano, Italija; Giovanni Medical, 1998. (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Synthesis of sulfamethoxazole metabolites
Autori
Lovrek, Monika ; Zorc, Branka ; Butula, Ivan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstract book
/ Paoletti, R. - Milano : Fondazione Giovani Lorenzini, Milano, Italija; Giovanni Medical, 1998
Skup
Fourth European Congress of Pharmaceutical Sciences
Mjesto i datum
Milano, Italija, 13.09.1998. - 15.09.1998
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
sulfamethoxazole; metabolite; synthesis
Sažetak
Sulfamethoxazole (SMX) is a well known antibacterial drug. Most serious side effects of sulfamethoxazole and other sulfonamides are hypersensitivity reactions, the pathogenesis of which has been suggested to be mediated by reactive metabolites. We report here the new synthetic paths for preparation of sulfamethoxazole: 4-nitrozo-N-(5-methy-3-isoyazolyl)benzenesulfonamide (SMX-NO), 4-nitro-N-(5-methy-3-isoxazolyl) benzenesulfonamide (SMX-NO2), azoxybenzene-4,4-(N-5-methy-3-isoxazolyl)disulfonamide (SMX-AZ), N-(4-aminobenzenesulfoniyl)-3-oxo-butyramidine (SMX-AD) and 4-hydroxylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide (SMX-HA). Such compounds may be useful in the development of rapid, accurate diagnostic tests for hypersensitivity of sulfamethoxazole.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
