Pregled bibliografske jedinice broj: 213893
Peptidoglycan monomer - product of biotechnology with immunomodulatory properties
Peptidoglycan monomer - product of biotechnology with immunomodulatory properties // Immuno-modulatory drugs / Kniewald, Zlatko (ur.).
Zagreb: Medicinska naklada ; Hrvatsko Društvo za Biotehnologiju, 2005. str. 137-143
CROSBI ID: 213893 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Peptidoglycan monomer - product of biotechnology with immunomodulatory properties
Autori
Halassy, Beata ; Habjanec, Lidija ; Tomašić, Jelka
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Immuno-modulatory drugs
Urednik/ci
Kniewald, Zlatko
Izdavač
Medicinska naklada ; Hrvatsko Društvo za Biotehnologiju
Grad
Zagreb
Godina
2005
Raspon stranica
137-143
ISBN
953-176-315-1
Ključne riječi
peptidoglycan monomer, adjuvant, antimetastatic, immunorestorative, metabolism of peptidoglycan
Sažetak
Peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGln-mesoDpm(eNH2)-D-Ala-D-Ala, (PGM, PLIVA, Croatia) is a natural compound originating from bacterial peptidoglycan. It was produced by a simple biotechnology procedure1. Brevibacterium divaricatum was cultured in the early exponential phase of growth in the presence of penicillin, that led to the accumulation of complex, soluble peptidoglycan (PG) - containing material in the culture fluid. Digestion of PG polymer with lysozyme and subsequent purification of hydrolysis products led to the isolation of PGM. It is a non-toxic, an apyrogenic and a water-soluble compound with completely defined chemical structure. Its immunostimulative properties, resulting in adjuvant, antitumour, antimetastatic and immunorestorative activities in different models have been reviewed.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija
