Pregled bibliografske jedinice broj: 213048
Uloga farmakogenetičkih varijacija u terapiji depresije
Uloga farmakogenetičkih varijacija u terapiji depresije, 2005., doktorska disertacija, Medicinski fakultet, Zagreb
CROSBI ID: 213048 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Uloga farmakogenetičkih varijacija u terapiji depresije
(The role of pharmacogenetic variations in the therapy of depression)
Autori
Božina, Nada
Vrsta, podvrsta i kategorija rada
Ocjenski radovi, doktorska disertacija
Fakultet
Medicinski fakultet
Mjesto
Zagreb
Datum
11.10
Godina
2005
Stranica
116
Mentor
Stavljenić Rukavina, Ana
Ključne riječi
farmakogenetičke varijacije; depresija;
(pharmacogenetic variations; depression)
Sažetak
Genetic variations of metabolic enzymes and transporter proteins are important determinants of pharmacotherapy efficacy and toxicity. In addition, interindividual, interethnic differences in the prevalence of genetic variations are signifficanz. In this study, pharmacogenetic analysis was performed in Croatian healthy population and patients with depression. The influence of genetic variations of metabolic enzymes: CYP2C9, CYP2C19, CYP2D6, CYP3A4 and transporter proteins: P-glycoprotein (MDR1) and serotonin transporter (SERT) on pharmacologic and toxicologic effects of major depression therapy were investigated. The study included 286 healthy subjects and 114 patients with major depression.
Izvorni jezik
Hrvatski
