Pregled bibliografske jedinice broj: 212683
Doppler perfusion index changes in patients with colorectal cancer liver metastases
Doppler perfusion index changes in patients with colorectal cancer liver metastases // World Congress of the International Association of Surgeons and Gastroenterologists
Zürich, Švicarska, 2004. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 212683 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Doppler perfusion index changes in patients with colorectal cancer liver metastases
Autori
Kopljar, Mario ; Horžić Matija, Brkljačić, Boris ; Doko Marko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
World Congress of the International Association of Surgeons and Gastroenterologists
Mjesto i datum
Zürich, Švicarska, 15.09.2004. - 20.09.2004
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
colorectal cancer; doppler perfusion index; liver metastases
Sažetak
Colorectal cancer is the second most common cause of cancer death. Approximately 50% of patients develop liver metastases within two years. At least 30% of colorectal cancer patients with apparently no liver involvement harbor liver metastases at the time of surgery. Detection of these micro metastases could direct those patients for adjuvant treatment modalities and more intensive surveillance. It was recently found that the ratio of hepatic arterial blood flow and the sum of hepatic arterial and portal blood flow (called Doppler perfusion index - DPI) was significantly greater in colorectal patients with liver metastases. However, the cause of this effect is still unknown. Hepatic arterial and portal blood flow were analyzed in three groups of patients (healthy controls, patients with primary colorectal cancer without apparent liver metastases and patients with obvious liver metastases). Patients with liver metastases had significantly increased arterial hepatic blood flow compared to patients without liver involvement (p<0.025). Healthy controls had significantly larger portal vein cross-sectional area (p<0.025), as well as portal blood flow (p<0.025), compared to patients with colorectal cancer and patients with liver metastases. Doppler perfusion index was significantly greater in patients with liver metastases compared to both healthy controls (p<0.025) and patients with primary colorectal cancer (p<0.025). These results prove the potential role of DPI in selecting patients for adjuvant treatment. Also, significantly reduced portal blood flow in patients with either solitary primary colorectal cancer or liver metastases speaks strongly in favor of the existence of the humoral vazoactive substance in colorectal cancer patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
