Naslov
The diagnostic value of cellular antigen stimulation test (CAST) in patients with atopic dermatitis

Autori
Rudolf, Maja ; Milavec-Puretić, Višnja ; Lipozenčić, Jasna ; Malenica, Branko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Annual Meeting 2005 / - , 2005

Skup
Croatian Immunological Society Annual Meeting

Mjesto i datum
Božava, Hrvatska, 29.09.2005. - 02.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
cellular antigen stimulation test (CAST) atopic dermatitis

Sažetak
Atopic dermatitis (AD) is chronically reccurent inflammatory skin disorder characterized by eczematous skin lesions that affect 10-20% of the population. Although AD is commonly detect in infancy and usually represent the first manifestation of atopy, it can present later in life and persist in adulthood. This chronic condition is associated with asthma and/or allergic rhinitis. The aim was to evaluate the diagnostic value of the antigen stimulation test (CAST) in diagnosis of allergic reactions to inhalant and foof allergens in patients with atopic dermatitis and rhinitis. CAST was based of sulfidoleukotriene (sLT, LTC4, LTD4, and LTE4)production after in vitro specific alleren cell stimulation. 44 patients at the age from 3 month to 54 years with a history of hypersensitivity reactions to Der p, Der f, grass pollen, ragwed pollen, milk, egges and soya were included in study. The results of the study show that 69% (25/36) of patients had positive CAST to Der p, 61% (14/23) of patients to Der f 82% (9/11) od patients to grass pollen, 70% (7/10) of patients to ragweed pollen, 24% (5/25) of patients to milk, 68% (19/28) to eggs and 31% (5/16) to soya. We concluded that cellular releasibility, by quantification of mediator production allow for a better detection of hypersensitivity reactions in the patients with AD and rhinitis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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