Naslov
Evaluation of Acute Phase Proteins and Acute Phase Index in Dogs with Naturally Occuring Babesiosis
(Evaluation of acute phase proteins and acute phase index in dogs with naturally occuring babesiosis)

Autori
Matijatko, Vesna ; Kučer, Nada ; Brkljačić, Mirna ; Kiš, Ivana ; Grden, Darko ; Mrljak, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings the 20th International Conference of the World Association for the Advancement of Veterinary Parasitology / - Christchurch, 2005, 103-103

Skup
The 20th International Conference of the World Association for the Advancement of Veterinary Parasitology

Mjesto i datum
Christchurch, Novi Zeland, 16.10.2005. - 20.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Acute Phase Proteins ; Acute Phase Index ; Dog ; Babesiosis

Sažetak
Acute phase proteins (APP) are plasma proteins the concentration of which alters following infection, inflamation or trauma. Measurement of concentration of selected APPs can be used to evaluate diagnosis, prognosis and monitoring of treatment of inflammatory or infections conditions. Interpetive benefit can be further enhanced by the acute phase proteins index (APP-Index). APP-Index has been used to evaluate the animals health status and to predict the response to the treatment. The acute phase reaction in naturally occurring canine babesiosis has been poorly described. The purpose of this study was the evaluation of APPs and APP-Index in dogs with babesiosis before and during the treatment. 38 dogs presented at the Veterinary hospital with clinical signs of acute babesiosis were prospectively studied. In all cases Babesia canis infection was confirmed by detection of the parasite using Romanowsky-stained thin blood smears. The control group consisted 13 healthy dogs, clinicali normal and aparasitemic. Blood was collected before treatment with imidocarb diproprionat (Imizol, Shering Plough) and on the 1st, 2nd, 4th and 9th day after treatment. The AGP plasma concentration was measured using radial immunodiffusion test kit (Canine AGP, Tridelta Development Limited). Serum was analysed for levels of albumin and plasma for levels of fibrinogen. APP-Index was calculated as the ratio between to positive and one negative APP. Statistical analyses of the data were carried out by the Student`s T-test and compared by ANOVA at p less than 0, 05 significance level. Our results showed great AGP and fibrinogen response with the highest mean concentrations on the first day after treatment. Dogs with infections had significantly higher concentration of AGP before the treatment, 1st and 2nd day after the treatment that did healthy dogs. Fibrinogen had the same trend. The mean values of fibrinogen concentrations showed increment to the 1st day of the study and then begins to fall. There were no significant differences between any of the albumin groups. APP-Index value obtained for babesiosis animals on day 0, 1st and 2nd were significantly higher than control values. A gradual decrease of APP-Index was observed during the therapy. Results obtained in this study suggested that marked acute-phase response was presented and APP-Index could be an aid to suspect about babesiotic dogs and to monitor their response to treatment.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA