Naslov
Physiological Role of IL-15 and IL-18 at the Maternal-Fetal Interface

Autori
Laškarin, Gordana ; Štrbo, Nataša ; Bogović Crnčić, Tatjana ; Juretić, Koraljka ; Ledee Bataille, Nathalie ; Chaouat, Gerard ; Rukavina, Daniel

Izvornik
Chemical immunology and allergy (1660-2242) 89 (2005); 10-25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Decidua; IL-15; IL-18

Sažetak
Here, we review recent studies about two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate immunity and both Th1- and Th2-driven immune responses depending of cytokine milieu. We addressed possible role of these two cytokines in induction of the IFN-gamma production as a key molecule in vascular remodeling during early pregnancy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA