Naslov
Effects of Local Administration of Propolis and Its Polyphenolic Compounds on Tumor Formation and Growth

Autori
Oršolić, Nada ; Terzić, Svjetlana ; Mihaljević, Željko ; Šver, Lidija ; Bašić, Ivan

Izvornik
Biological & pharmaceutical bulletin (0918-6158) 28 (2005), 10; 1928-1933

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
water-soluble propolis extract; caffeic acid; caffeic acid phenethyl ester; mice; tumor growth

Sažetak
Many dietary constituents are chemopreventive in animal models, and experiments with cultured cells are revealing various potential mechanisms of action. Compounds classified as blocking agents can prevent, or greatly reduce, initiation of carcinogenesis, or suppressing agents can act on cell proliferation. Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE), members of the polyphenolic compounds, are present in high concentrations in medicinal plants and propolis, a natural beehive product. A water-soluble extract of propolis (WSDP) and two components of propolis, CA and CAPE were investigated for direct antitumor activity in vivo and in vitro. The local presence of CA and CAPE in the tissue caused a significant delay in tumor formation and increased life span 29.30 to 51.73%, respectively. CA and CAPE, but not WSDP, significantly suppressed human HeLa cervical carcinoma cell proliferation in vitro. Based on these results, we postulate that the antitumor activity of polyphenolic compounds includes direct cytotoxic effects on tumor cells.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA