Pregled bibliografske jedinice broj: 207157
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6 // Treći hrvatski kongres farmakologije s međunarodnim učešćem
Zagreb, Hrvatska, 2001. (pozvano predavanje, nije recenziran, sažetak, znanstveni)
CROSBI ID: 207157 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6
Autori
Volarević, Siniša
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Treći hrvatski kongres farmakologije s međunarodnim učešćem
Mjesto i datum
Zagreb, Hrvatska, 19.09.2001. - 21.09.2001
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
cell proliferation; cell growth; ribosomal protein S6
Sažetak
Because ribosome biogenesis plays an essential role in cell proliferation, control mechanisms may have evolved to recognize lesions in this critical anabolic process. To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice. Unexpectedly, livers from fasted animals deficient in S6 grew in response to nutrients even though biogenesis of 40S ribosomes was abolished. However, liver cells failed to proliferate or induce cyclin E expression after partial hepatectomy, despite formation of active cyclin D-CDK4 complexes. These results imply that abrogation of 40S ribosome biogenesis may induce a checkpoint control that prevents cell cycle progression.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
