Naslov
Evaluation of cytogenetic damage in nuclear medicine personnel occupationally exposed to low-level ionising radiation

Autori
Garaj-Vrhovac, Vera ; Kopjar, Nevenka ; Poropat, Mirjana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the sixth symposium of the Croatian radiation protection association / Garaj-Vrhovac, Vera ; Kopjar , Nevenka ; Miljanić, Saveta - Zagreb, 2005, 200-205

Skup
Sixth Symposium of the Croation Protection Association

Mjesto i datum
Stubičke Toplice, Hrvatska, 18.04.2005. - 20.04.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
occupationally exposed; ionising radiation; nuclear medicine; cytogentic damage
(occupationally exposed; ionising radiation; nuclear medicine; cytogenetic damage)

Sažetak
Despite intesive research over the last few decades, there still remains considerable uncertainty as to the genetic impact of ionosing radiation on human populations, particularly at low levels. The aim of this study was to provide data on genetic hazards associated with occupational exposure to low doses of ionising radiation in nuclear medicine departments. The assessment of dNA damage in peripheral blood lymphocytes of medical staff was performed using the chromosome aberration (CA) test. Exposed subjects showed significantly higher frequencies of CA than controls. There were significant inter-individual differences in DNA damage within the exposed population, indicating differences in genome sensitivity. Age and gender were not confounding factors, while smoking enhanced the levels of DNA damage only in control subjects. The present study suggests that chronic exposure to low doses of ionising radiation in nuclear medicine departments causes genotoxic damage. Therefore, to avoid potential genotoxic effects, the exposed medical personnel should minimise radiation exposure wherever possible. Our results also point to the significance of biological indicators providing information about the actual risk to the radiation exposed individuals.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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