Pregled bibliografske jedinice broj: 203157
Integrin alpha(5)beta(1) ligands: Biological evaluation and conformational analysis
Integrin alpha(5)beta(1) ligands: Biological evaluation and conformational analysis // ChemBioChem : a European journal of chemical biology, 6 (2005), 2; 272-276 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 203157 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Integrin alpha(5)beta(1) ligands: Biological evaluation and conformational analysis
Autori
Zimmermann, Dunja ; Guthöhrlein, Eckhart W. ; Malešević, Miroslav ; Sewald, Katherina ; Wobbe, Lutz ; Heggemann, Carolin ; Sewald, Norbert
Izvornik
ChemBioChem : a European journal of chemical biology (1439-4227) 6
(2005), 2;
272-276
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cell adhesion; conformation analysis; integrins; peptides; surface plasmon resonance
Sažetak
Breaking up is easy. Integrin a5b1 is a cell-surface receptor involved in many physiological and pathological processes. Small cyclic peptides can influence the interaction between this receptor and its natural ligand, fibronectin. The peptide shown, c-(-Arg-Gly-Asp-d-Phe- Val-b-Ala-), can bind a5b1 with submicromolar affinity. A conformational analysis of the peptide provided information on the structural properties responsible for binding to a5b1.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- Biological Abstracts
- Chemical Abstracts
