Naslov
Priprava i lipazama katalizirano O-acetiliranje ferocenskih alkohola
(Preparation and lipase catalyzed O-acetylation of ferrocene alcohols)

Autori
Đaković, Senka ; Horvat, Petar ; Lapić, Jasmina ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. hrvatski skup kemičara i kemijskih inženjera : Knjiga sažetaka / Rapić, Vladimir ; Rogošić, Marko - Zagreb : Hrvatsko društvo Kemija u industriji, 2005, 116-116

ISBN
953-6894-23-8

Skup
Hrvatski skup kemičara i kemijskih inženjera (19 ; 2005)

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferocenski alkoholi; lipaze; enantioselektivnost
(ferrocene alcohols; lipase; enantioselectivity)

Sažetak
The development of new synthetic methods for the preparation of non-racemic chiral ferrocenes is an important goal in view of the use of these compounds as ligands in asymmetric synthesis [1]. Ferrocenyl derivatives bearing a stereocenter in beta-position of the side chain have received much less attention due to the lack of suitable homochiral starting materials [2]. In continuation of our research on biocatalyzed acylations of ferrocene carbinols [3], secondary beta-ferrocenylalkanols 1-3, as well as the corresponding acetates 4-6 were synthesized. The alcohols prepared were submitted to enantioselective biotransesterifications modifying several reaction parameters (temperature, solvent, acyl donor and microbial lipases) and monitored their effect on these biotransformations. The course of the conversions was followed by HPLC technique and the optical purity of the compounds prepared was examined on the chiral columns.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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