Naslov
Sinteza ferocenskih dipeptida
(Synthesis of Ferrocene Containing Dipeptides)

Autori
Barišić, Lidija ; Kraatz, Heinz-Bernhard ; Mahmoud, Khaled ; Metzler-Nolte, Nils ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. Hrvatski skup kemičara i kemijskih inženjera: Knjiga sažetaka / Škare, Danko ; Rapić, Vladimir ; Rogošić, Marko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2005, 113-113

Skup
XIX. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ferocenski dipeptidi; kristalna struktura; spektroskopija; elektrokemijske metode
(ferrocene containing dipeptides; X-ray; spectral and electrochemical methods)

Sažetak
In our recent work we prepared several oligopeptides of the type Boc(Ala)nFca(Ala)mOMe (n = 0-2 ; m = 1-3) starting from 1-(N-butoxycarbonylamino)-ferrocene-1-carboxylic acid (1, Boc-Fca) and using EDC/ HOBt protocol. Inter alia we demonstrated that dipeptide (n=0 ; m=1) exerted helical chirality caused by intramolecular H-bond [1, 2]. These results encouraged us to prepare the series of the analogous dipeptides BocFca(AA) OMe (2) (AA = Pro, Phe, Met, Leu, Cys, His, Lys, Gly, Val) as well as the dipeptides X(AA)FcaOMe (3 ; AA = Ala, Ser ; X = Boc, Fmoc). The compounds 2 were synthesized by coupling Boc-Fca 1 and esters of natural amino acids using EDC/ HOBt method. The preparation of dipeptides 3 was performed by reaction of N-deprotected Boc-Fca-OMe with X-AAs under the similar conditions. The characterization of dipeptides prepared was carried out in crystalline state and in solution, by means of X-ray, spectral and electrochemical methods.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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