Naslov
Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo

Autori
Pavlak, Marina ; Radačić, Marko ; Jerčić, Jure ; Stojković, Ranko ; Vlahović, Ksenija ; Žinić, Biserka

Izvornik
Veterinarski arhiv (0372-5480) 75 (2005), 4; 311-316

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
uracil ; citozin ; N-sulfonil-deivati pirimidinskih nukleobaza ; miš
(uracil ; cytosine ; N-sulfonilpyrimidine derivatives ; mice)

Sažetak
The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-1-sulfonylcytosine (4, 12) and N-1, NH-4-disulfonylcytosine (13) were evaluated in this study. All experiments were performed on 10-14- week-old male and female c57bl/6 zgr mice weighing 22-25 g at the time of treatment. The obtained data showed that derivatives 1, 2, 7, 12 and 13 cause less toxicity than derivatives 4, 6, 8 and 9. Compounds 2, 7, 12 and 13 did not cause death in mice in doses of 3000 mg/kg. Uracil derivative 8 has shown the highest toxicity, its acute toxic dose being 150 mg/kg, similar to the acute toxic dose of 5-fluorouracil.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

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