Naslov
Possible mechanisms involved in the action of imipramine and dihydroergosine on the 5-HT syndrome in rats

Autori
Peričić, Danka

Izvornik
European journal of pharmacology (0014-2999) 183 (1990), 5; 1965-1966

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
imipramine ; dihydroergosine ; 5-HT syndrome ; rats ; 8-OH-DPAT ; propranolol ; ritanserin

Sažetak
Our recent studies (Peričić and Manev, 1988)have shown that the classic antidepressant imipramine and a possible antidepressant dihydroergosine (Peričić and Manev, 1987) stimulate long-lastingly and dose-dependently the serotonin (5-HT) syndrome in rats and myoclonus in guinea pigs, but inhibit the head-twitch response in mice and rats. In agreement with some previous studies we have suggested that imipramine and dihydroergosine simultaneously stimulate 5-HT1 and inhibit 5-HT2 receptors (Peričić and Manev, 1988). The present study was designed to further elucidate the mechanism of action of these drugs on the 5-HT syndrome. The results suggest that imipramine and dihydroergosine, unlike 8-OH-DPAT, stimulate the 5-HT syndrome in rats by a potentiation of effects of 5-HTP leading to stimulation of 5-HT1, presumably 5-HT1A receptors. The direct or indirect stimulation of 5-HT1A receptors that appears to be the consequence of dihydroergosine or imipramine administration is not triggered by the inhibition of 5-HT2 receptors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Document Type:Meeting Abstract

POVEZANOST RADA