Pregled bibliografske jedinice broj: 200052
The effects of antipsychotics on the GABA system
The effects of antipsychotics on the GABA system // Phenothiazines and Structurally Related Drugs: Basic and Clinical Studies / Usdin, Earl ; Eckert, Helmut ; Forrest, Irene S. (ur.).
New York (NY): Elsevier, 1980. str. 249-252
CROSBI ID: 200052 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The effects of antipsychotics on the GABA system
Autori
Peričić, Danka ; Walters, Judith R.
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Phenothiazines and Structurally Related Drugs: Basic and Clinical Studies
Urednik/ci
Usdin, Earl ; Eckert, Helmut ; Forrest, Irene S.
Izdavač
Elsevier
Grad
New York (NY)
Godina
1980
Raspon stranica
249-252
ISBN
0-444-00401-7
Ključne riječi
chlorpromazine, haloperidol, clozapine, GABA synthesis, GAD, substantia nigra, caudate nucleus, cingulate cortex, pyriform cortex, rats
Sažetak
The antipsychotic drugs (chlorpromazine, haloperidol, clozapine) appear to be able to cause some changes in GABA synthesis, although the nature of the changes depends on the brain region studied as well as the antipsychotic drug used. Unlike haloperidol, which in low doses decreased the synthesis of GABA in the substantia nigra and caudate nucleus, both chlorpromazine and clozapine appeared to increase GABA synthesis in the substantia nigra and pyriform cortex. Accordingly, the changes in GABA synthesis caused by these drugs do not appear to correlate with their ability to block dopamine receptors, neither to their ability to produce extrapyramidal side effects as the butyrophenone derivative produced effects different from those of chlorpromazine.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
