Pregled bibliografske jedinice broj: 199840
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma // Cancer letters, 238 (2006), 2; 224-229 doi:10.1016/j.canlet.2005.07.003 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 199840 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma
Autori
Grbeša, Ivana ; Ivkić, Mirko ; Pegan, Boris ; Gall-Trošelj, Koraljka
Izvornik
Cancer letters (0304-3835) 238
(2006), 2;
224-229
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
IGF2 ; laryngeal squamous cell carcinoma ; imprinting ; promoter usage
Sažetak
The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
