Naslov
Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates

Autori
Zovko, Marijana ; Barbarić, Monika ; Zorc, Branka ; Hafner, Anita ; Filipović-Grčić, Jelena

Izvornik
Acta pharmaceutica (1330-0075) 55 (2005), 2; 169-176

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
fenoprofen; gemfibrozil; polymer drug conjugate; styrene-maleic acid copolymer

Sažetak
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA