Naslov
Synthesis and biological evaluation of new 2-amino-substituted benzothiazoles

Autori
Ćaleta, Irena ; Karminski-Zamola, Grace ; Kralj, Marijeta ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the Contributions of the Joint Meeting on Medicinal Chemistry ; u Scientia pharmaceutica 73 (2005) (S) / Erker, Th. ; Reznicek, G. - Beč : Österreichischen Pharmazeutischen Gesellschaft, 2005, S253-v

Skup
Joint Meeting on Medicinal Chemistry

Mjesto i datum
Beč, Austrija, 20.06.2005. - 23.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
2-amino-substituted benzothiazoles; multistep synthesis; biological activity

Sažetak
Over the past decade development of small molecule Src family kinase inhibitors has been an area of major pharmaceutical interest [1]. A large number of benzothiazole derivatives are of considerable biological and chemical interest [2]. 2-Amino-substituted benzothiazoles are reported as inhibitors of Src family kinases [3]. We prepared in multistep synthesis a series of new 2-amino substituted benzothiazoles 1-8 from 4-aminobenzonitrile. All compounds were characterized by IR, 1H- and 13C-NMR spectroscopy and elemental analysis. [1] J. Das, J. Lin, R. V. Moquin, Z. Shen, S. H. Spergel, et al., Bioorg.&Med. Chem. Lett., 13 (2003) 2145-2149. [2] T. D. Bradshaw, F. G. Stevens, A. D. Westwell, Current Med. Chem., 8 (2001) 203-208. [3] J. Das, R. V. Moquin, J. Lin, C. Liu, A. M. Doweyko, et al., Bioorg.&Med. Chem. Lett., 13 (2003) 2587-2590.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA