Pregled bibliografske jedinice broj: 197418
On the mechanism of immunostimulatory activity of monomeric peptidoglycans
On the mechanism of immunostimulatory activity of monomeric peptidoglycans // Periodicum biologorum, 81 (1979), 155-157 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 197418 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
On the mechanism of immunostimulatory activity of monomeric peptidoglycans
Autori
Hršak, Ivo ; Tomašić, Jelka ; Pavelić, Krešimir ; Benković Kušić, Borka
Izvornik
Periodicum biologorum (0031-5362) 81
(1979);
155-157
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
immunostimulatory activity; peptidoglycan monomer; mitogenic activity
Sažetak
Mitogenic activity of immunostimulatory peptidoglycan monomer (PGM) was tested in vitro in short term cultures of mouse lymph node cells containing different quantities of PGM. Cultures stimulated with phytohaemagglutinin (PHA) or concavalin A (Con A) served as positive controls. As expected, PHA and Con A amplified the incorporation of radioactive thymidine into lymphocytes. PGM showed no mitogenic acitvity. Only the lymphocytes of the cultures containing 1 microgram of PGM were weakly activated. The presence of PGM suppressed even the stimulatory activity of PHA and Con A. In conclusion, PGM very probably is not a mitogen, or is only a weak one at strictly defined dose in relation to the lymphocyte number.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
