Pregled bibliografske jedinice broj: 197357
Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes
Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes // Biological Chemistry Hoppe-Seyler, 371 (1990), 687-692 doi:10.1515/bchm3.1990.371.2.687 (međunarodna recenzija, članak, znanstveni)
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Naslov
Protective Role of Transforming Growth Factor β (TGF β) in Tumor-Induced Degradation of Basement Membranes
Autori
Pavelić, Krešimir ; Despot Slade, Neda ; Levanat, Sonja ; Časl, Tino
Izvornik
Biological Chemistry Hoppe-Seyler (0177-3593) 371
(1990);
687-692
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
transforming growth factor beta ; basement membrane ; fibrosarcoma cells ; collagenase
Sažetak
Human fibrosarcoma cells derived from a patient with multiple metastases extensively degrade artificial basement membranes (BM) and secrete interstitial type of collagenase, a proteolytic enzyme responsible for degradation of type I collagen. Exposure of invasive cell line to TGF β abrogates destruction of BM.TGF β reduces collagenase activity and stimulates specific metalloproteinase inhibitor (TIMP) in invasive tumor cells. We preassume that TGF β could play a protective role in tumor invasion.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
