Naslov
Substance immunologically cross-reactive with insulin (SICRI) stimulates cell division

Autori
Osmak, Maja ; Sirotković, Maja ; Levanat, Sonja ; Korbelik, Mladen ; Pavelić, Krešimir

Izvornik
Oncology (0030-2414) 46 (1989), 1; 54-57

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
substance immunologically cross-reactive ; insulin ; SICRI ; cell division

Sažetak
A substance immunologically cross-reactive with insulin (SICRI) was isolated and purified from murine melanoma B16. Biochemical and biological data provide evidence that SICRI and insulin are two distinct biologically active agents. In vitro, SICRI has stimulated the DNA and protein synthesis, cell growth or colony-forming ability of 19 normal and transformed cell lines of human and rodent origin. It indicates that SICRI is a potent nonspecific growth factor. The most pronounced stimulatory effect of SICRI on proliferative capacity of cells is observed with cells at Go/G1 point of the cell cycle.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA