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Pregled bibliografske jedinice broj: 196537

Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product

Novak, Predrag; Tepeš, Predrag; Cindrić, Mario; Ilijaš, Marina; Dragojević, Snježana; Mihaljević, Krešo
Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product // Journal of chromatography. A, 1033 (2004), 2; 299-303 doi:10.1016/j.chroma.2004.01.055 (međunarodna recenzija, članak, znanstveni)

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Naslov
Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product

Autori
Novak, Predrag ; Tepeš, Predrag ; Cindrić, Mario ; Ilijaš, Marina ; Dragojević, Snježana ; Mihaljević, Krešo

Izvornik
Journal of chromatography. A (0021-9673) 1033 (2004), 2; 299-303

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nuclear magnetic resonance spectroscopy; acarbose

Sažetak
Directly coupled LC-MS and LC-NMR were applied to identify and structurally characterize an acarbose degradation product A in acidic media. A comparative analysis of the stop-flow LC-NMR (1H and TOCSY) and LC-MS data provided evidence that A is structurally related to acarbose, differing from the parent compound in a number of subunits present in the molecule. Spectral analysis revealed that A was the alpha-glucosidase inhibitor amylostatin XG. Complementary information obtained from the two methods led to the structural elucidation of A which was later corroborated by high-resolution NMR spectroscopy of the isolated molecule.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA

Projekti:
0119641

Ustanove:
Pliva-Istraživački institut,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Marina Ilijaš (autor)

Avatar Url Predrag Novak (autor)

Avatar Url Predrag Tepeš (autor)

Avatar Url Krešo Mihaljević (autor)

Avatar Url Mario Cindrić (autor)

Avatar Url Snježana Dragojević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com ac.els-cdn.com dx.doi.org

Citiraj ovu publikaciju:

Novak, Predrag; Tepeš, Predrag; Cindrić, Mario; Ilijaš, Marina; Dragojević, Snježana; Mihaljević, Krešo
Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product // Journal of chromatography. A, 1033 (2004), 2; 299-303 doi:10.1016/j.chroma.2004.01.055 (međunarodna recenzija, članak, znanstveni)
Novak, P., Tepeš, P., Cindrić, M., Ilijaš, M., Dragojević, S. & Mihaljević, K. (2004) Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product. Journal of chromatography. A, 1033 (2), 299-303 doi:10.1016/j.chroma.2004.01.055.
@article{article, author = {Novak, Predrag and Tepe\v{s}, Predrag and Cindri\'{c}, Mario and Ilija\v{s}, Marina and Dragojevi\'{c}, Snje\v{z}ana and Mihaljevi\'{c}, Kre\v{s}o}, year = {2004}, pages = {299-303}, DOI = {10.1016/j.chroma.2004.01.055}, keywords = {nuclear magnetic resonance spectroscopy, acarbose}, journal = {Journal of chromatography. A}, doi = {10.1016/j.chroma.2004.01.055}, volume = {1033}, number = {2}, issn = {0021-9673}, title = {Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product}, keyword = {nuclear magnetic resonance spectroscopy, acarbose} }
@article{article, author = {Novak, Predrag and Tepe\v{s}, Predrag and Cindri\'{c}, Mario and Ilija\v{s}, Marina and Dragojevi\'{c}, Snje\v{z}ana and Mihaljevi\'{c}, Kre\v{s}o}, year = {2004}, pages = {299-303}, DOI = {10.1016/j.chroma.2004.01.055}, keywords = {nuclear magnetic resonance spectroscopy, acarbose}, journal = {Journal of chromatography. A}, doi = {10.1016/j.chroma.2004.01.055}, volume = {1033}, number = {2}, issn = {0021-9673}, title = {Combined use of liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry for the characterization of an acarbose degradation product}, keyword = {nuclear magnetic resonance spectroscopy, acarbose} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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  • CA Search (Chemical Abstracts)

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