Naslov
Growth factors in human tumors

Autori
Krušlin, Božo ; Levanat, Sonja ; Baltić, Vladimir ; Milković, Dubravka ; Pavelić, Jasminka ; Spaventi, Radan ; Spaventi, Šime ; Pavelić, Krešimir

Izvornik
Research in experimental medicine (0300-9130) 189 (1989), 2; 91-99

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
growth factors ; human tumors ; peptides ; tumor progression

Sažetak
Various human tumor tissues contain different growth factors. In some cases progression of tumors is paralleled by elevated levels of these substances in blood or in tumor tissue. There is evidence that these growth promoting peptides might stimulate tumor growth. The growth of most tumors was associated with insulin-like substances (MW 45 000). We isolated and purified a substance immunologically cross-reactive with insulin (SICRI) from human melanoma. We found the molecular weight of affinity purified SICRI to be approximately 120 000. Our in vitro experiments with human renal carcinoma cells and growth factors suggest an important role of these molecules in tumor progression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA