Naslov
P185neu is expressed in zolk sac during postimplantation development

Autori
Knežević, Vladimir ; Spaventi, Radan ; Poljak, Ljiljana ; Slade, Neda ; Švajger, Anton ; Pavelić, Krešimir

Izvornik
Journal of anatomy (0021-8782) 185 (1994), 1; 181-187

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rat embryo ; p185neu oncogene

Sažetak
We have shown that the neu oncogene product (p185(neu)) is not present in the rat embryo before organogenesis. However, coincident with the onset of organogenesis, p185(neu) was detected in neural and connective tissue as well as in the secretory epithelium as was described by Kokai et al. (1987). In addition, p185(neu) is also expressed in the rat visceral yolk sac (VYS) endodermal cells but not in the mesenchymal and mesothelial layers of the same structure nor in the amnion. The first detectable sign of p185(neu) expression in VYS was found at d 11 of gestation and the levels of protein increased towards the end of pregnancy. In the yolk sac carcinoma (YSC), which is considered to be the malignant counterpart of the rat yolk sac, p185(neu) was observed only within columnar epithelial cells (the visceral component of the neoplasm) while parietal endoderm-like cells were devoid of detectable protein. From d 9 of pregnancy up to delivery some of the trophoblastic giant cells also showed a faint to moderate immunoreactivity. Results are presented which would indicate a possible role of p185(neu) in rat embryogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA