Naslov
Efficacy of N-sulfoniypyrimidine derivatives and hyperthermia on the mouse tumour growth

Autori
Pavlak, Marina ; Jerčić, Jure ; Vlahović, Ksenija ; Radačić Aumiler, Matea ; Žinić, Biserka ; Radačić, Marko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd International Symposium on Targeted Anticancer Therapies TAT in: Annals of Oncology, Vol. 16 (Suppl. 3), / - Amsterdam, 2005

Skup
3rd Intern. Symposium on Targeted Anticancer Therapies,

Mjesto i datum
Amsterdam, Nizozemska, 03.03.2005. - 05.03.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
anaplastic mamary carcinoma; N-sulfonylcytosine derivatives; hyperthermia; tumor gro

Sažetak
Background: New compounds have been firstly tasted on different mouse tumour models and evaluated as potential anticancer drugs. Among many anticancer compounds, heterocyclic organic compounds have been recently more tested by us in order to find antitumour activity. Pyrimidine is one of heterocyclins, which showed interesting cytotoxic effect. Newly synthesizes N-sulfonyl derivatives of pyrimidine have shown potential anticancer activity in our study. Therefore, in this study we wanted to investigate antitumour activity of newly N-sulfonyl derivatives of pyrimidine nucleobases and local hyperthermia on the growth of anaplastic mammary carcinoma. Material and methods: In this study we used a transplantable mouse mammary carcinoma (TMMCa). Tumour cells (106) were injected into the footpad of the right hind leg (intrasolearly) of CBA mice. Tumour bearing mice have been treated with N-sulfonylpyrimidine derivatives or with 5-fluorouracil (positive control) with and without hyperthermia (43, 0oC/60 min). The end point was tumour growth time (TGT). N-sulfonylpyrimidine derivatives have been synthesized in Rudjer Boskovic Institute. Antitumor activity was examined for: 1-(p-toluenesulfonyl)cytosine (4H) and 1-(p-toluenesulfonyl)cytosine hydrochloride (4HxHCl). Results: The presented results show that both examined N-sulfonylpyrimidine derivatives (4H and 4HxHCl) had strong antitumour activity. Local hyperthermia alone had statistically significant antitumour activity. But hyperthermia in combination with these derivatives enhanced the antitumour activity of 1-(p-toluenesulfonyl)cytosine hydrochloride (4HxHCl). All new compounds showed similar or slightly better antitumour effects comparing to 5-fluorouracil.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Sazetak objavljen u CC casopisu

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