Naslov
Sterolidi:kreiranje, sinteza i biološka aktivnost
(Sterolides:design, synthesis and biological evaluation)

Autori
Tomašković, Linda ; Komac, Marijana ; Makaruha Stegić, Oresta ; Poljak, Višnja ; Selmani, Selvira ; Šijan, Gordana ; Hrvačić, Boška ; Marković, Stribor ; Merćep, Mladen ; Mesić, Milan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX. hrvatski skup kemičara i kemijskih inženjera / ? - Zagreb, 2005, 70-70

Skup
XIX. hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
sterolides; antiinflammatory; asthma

Sažetak
Although inhaled steroids are the most effective therapy known for asthma, their use over long periods is associated by a number of severe side effects. Several strategies have been employed in development of "safer" anti-inflammatory steroids. We used a novel "sterolide" concept (steroid-macrolide conjugates1-3) where we combined property of macrolides to preferentially accumulate in immune cells, especially in phagocyte cells (peripheral blood mononuclear cells, peritoneal and alveolar macrophages) with potent anti-inflammatory activity of classic steroids. Such sterolide molecules show excellent anti-inflammatory activity in several animal models with little or no systemic effects otherwise seen with standard steroids. Lead molecule is currently in the late preclinical development stage.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

Napomena
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