Naslov
11H-dibenzo[b, f]oksepin-10-on i 11H-dibenzo[b, f]tiepin-10-on kao ključne molekule u pripravi različitih dibenzo[e, h]azulena
(11H-Dibenzo[b, f]oxepin-10-one and 11H-dibenzofb, f]thiepin-10-one as core units in the synthesis of various dibenzo[e, h]azulenes)

Autori
Pešić, Dijana ; Ozimec Landek, Ivana ; Džapo, Iva ; Modrić, Marina ; Rupčić, Renata ; Trojko, Rudolf ; Merćep, Mladen ; Mesić, Milan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / Škare, Danko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2005

Skup
XIX. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Opatija, Hrvatska, 24.04.2005. - 27.04.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
dibenzo[b; f]oksepin-10-on; dibrenzo[b; f]tiepin-10-on; dibenzo[e; h]azuleni; protuupalno djelovanje; modificiranje strukture
(dibenzo[b; f]oxepin-10-one; dibrenzo[b; f]thiepin-10-one; dibenzo[e; h]azulenes; anti-inflammatory activity; modification)

Sažetak
Dibenzo[b, f]oxepines and dibenzo[b, f]thiepines were recognized as useful starting compounds for the synthesis of various dibenzo[e, h]azulenes which numerous derivatives show different pharmacological activities [1, 2]. Herein we wish to report some efficient syntheses of a few tetracyclic dibenzo[e, h]azulenes starting from 11H-dibenzo[b, f]oxepin-10-one and its sulphur analogue (1). Common synthetic strategy for the synthesis of different dibenzo[e, h]azulene scaffolds comprises formation of a-substituted ketones (by reaction of activated methylene group of ketones 1 with various reagents), which are further transformed into appropriate tetracyclic dibenzo[e, h]azulene system via nucleophilic substitution and elimination reaction mechanisms. According to target molecules requested, those tetracyclic compounds can be further transformed by different functional group interconversions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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