Naslov
Use of 11H-dibenzo[b, f]oxepin-10-one and 11H-dibenzo[b, f]thiepin-10-one as core units for the synthesis of various dibenzo[e, h]azulenes

Autori
Mesić, Milan ; Pešić, Dijana ; Ozimec Landek, Ivana ; Džapo, Iva ; Modrić, Marina ; Rupčić, Renata ; Trojko, Rudolf ; Merćep, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
XXIst European Colloquium on Heterocyclic Chemistry

Mjesto i datum
Sopron, Mađarska, 12.09.2004. - 15.09.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
dibenzo[e; h]azulenes; synthesis; 11H-dibenzo[b; f]oxepin-10-one; 11H-dibenzo[b; f]thiepin-10-one

Sažetak
The tricyclic structure of dibenzo[b, f]oxepines and dibenzo[b, f]thiepines was identified as an interesting scaffold which numerous derivatives show different pharmacological activities (antipsychotic, sedative, antidepressant, analgesic, antihypertensive, nonsteroidal anti-inflammatory, tromboxane antagonism). This broad biological activity prompted use of dibenzo[b, f]oxepines and dibenzo[b, f]thiepines as intermediates for the synthesis of various polycyclic compounds. Herein we wish to report some efficient syntheses of a few tetracyclic dibenzo[e, h]azulenes starting from 11H-dibenzo[b, f]oxepin-10-one and its sulphur analogue (1). According to target molecules requested, those tetracyclic compounds can be further transformed by different functional group interconversions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA