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Pregled bibliografske jedinice broj: 195527

Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.

Findrik, Zvjezdana; Vasić-Rački, Đurđa; Lütz, Stephan; Daußmann, Thomas; Wandrey, Christian
Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp. // Biotechnology letters, 27 (2005), 15; 1087-1095 doi:10.1007/s10529-005-8455-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 195527 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.

Autori
Findrik, Zvjezdana ; Vasić-Rački, Đurđa ; Lütz, Stephan ; Daußmann, Thomas ; Wandrey, Christian

Izvornik
Biotechnology letters (0141-5492) 27 (2005), 15; 1087-1095

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alcohol dehydrogenase ; cofactor regeneration ; enzyme deactivation ; enzyme kinetics

Sažetak
NADPH-dependent alcohol dehydrogenase (ADH) from Thermoanaerobacter sp. was kinetically characterized using reduction of acetophenone as a model. To achieve 98 % conversion of acetophenone, cofactor regeneration by oxidation of 2-propanol with the same enzyme was used. The enzyme was stable in the batch reactor. It showed to be highly enantioselective towards (S)-1- phenylethanol (ee > 99.5 %). Due to its high deactivation in continuously operated stirred tank reactor (kd = 0.0141 min-1) there was no way to keep high conversion of acetophenone at 98 %. The deactivation occurred in the repetitive batch as well. A mathematical model for the acetophenone reduction with cofactor regeneration describing the behaviour in a batch, repetitive-batch and continuously stirred tank reactor was developed.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo, Biotehnologija



POVEZANOST RADA

Projekti:
0125021

Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Đurđa Vasić-Rački (autor)

Avatar Url Zvjezdana Findrik Blažević (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com dx.doi.org

Citiraj ovu publikaciju:

Findrik, Zvjezdana; Vasić-Rački, Đurđa; Lütz, Stephan; Daußmann, Thomas; Wandrey, Christian
Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp. // Biotechnology letters, 27 (2005), 15; 1087-1095 doi:10.1007/s10529-005-8455-y (međunarodna recenzija, članak, znanstveni)
Findrik, Z., Vasić-Rački, Đ., Lütz, S., Daußmann, T. & Wandrey, C. (2005) Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.. Biotechnology letters, 27 (15), 1087-1095 doi:10.1007/s10529-005-8455-y.
@article{article, author = {Findrik, Zvjezdana and Vasi\'{c}-Ra\v{c}ki, \DJur\dja and L\"{u}tz, Stephan and Daußmann, Thomas and Wandrey, Christian}, year = {2005}, pages = {1087-1095}, DOI = {10.1007/s10529-005-8455-y}, keywords = {alcohol dehydrogenase, cofactor regeneration, enzyme deactivation, enzyme kinetics}, journal = {Biotechnology letters}, doi = {10.1007/s10529-005-8455-y}, volume = {27}, number = {15}, issn = {0141-5492}, title = {Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.}, keyword = {alcohol dehydrogenase, cofactor regeneration, enzyme deactivation, enzyme kinetics} }
@article{article, author = {Findrik, Zvjezdana and Vasi\'{c}-Ra\v{c}ki, \DJur\dja and L\"{u}tz, Stephan and Daußmann, Thomas and Wandrey, Christian}, year = {2005}, pages = {1087-1095}, DOI = {10.1007/s10529-005-8455-y}, keywords = {alcohol dehydrogenase, cofactor regeneration, enzyme deactivation, enzyme kinetics}, journal = {Biotechnology letters}, doi = {10.1007/s10529-005-8455-y}, volume = {27}, number = {15}, issn = {0141-5492}, title = {Kinetic modeling of acetophenone reduction catalyzed by alcohol dehydrogenase from Thermoanaerobacter sp.}, keyword = {alcohol dehydrogenase, cofactor regeneration, enzyme deactivation, enzyme kinetics} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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