Naslov
Über die Enantiomerentrennung durch Verteilung zwischen flüssigen Phasen. III. Selektivität der lipophilen Weinsäureester für chirale Ammonium- Salze verschiedener Konstitution und Konfiguration
(Separation of Enantiomers by Partition between Liquid Phases. 3. Selectivity of Lipophilic Tartaric Esters for Chiral Ammonium Salts of Different Contitutions and Configurations)

Autori
Prelog, Vladimir ; Mutak, Stjepan ; Kovačević, Krunoslav

Izvornik
Helvetica chimica acta (0018-019X) 66 (1983); 2279-2284

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Enantiomerentrennung; Verteilung zwischen flüssigen Phasen; Enantioselektivität
(Separation of enantiomers; resolution of racemates by partition cromatography; enantioselectivity)

Sažetak
Several methods are described which allow determination on a small scale of the enantiomer distribution constant Q, and the affinity coefficient P, which characterize the enantioselectivity and affinity of a lipophilic phase for ammonium sals of different constitution and configuration. The influence of concentration of the tartaric acid ester, temperature, concentration and type of the lypophilic anion on and P was investigated to find out favourable experimental conditions for resolutions of racemates by iterative process, e.g. partition chromatography. The relationship between Q and the configuration of aminoalcohols 1-12 was explored and the observed regularities are pointed out. In addition it was found that lipophilic tartaric acid esters are enantioselective to salts of threo-1, 2-diphenyl-1, 2-ethanediamine 13, and to phenylglycine and its derivatives 14-16.

Izvorni jezik
Ger

Znanstvena područja
Kemija

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