Naslov
Novel amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A, process for preparing the same, and uses thereof

Autori
Dumić, Miljenko ; Vinković, Mladen ; Orešić, Marina ; Meštrović, Ernest ; Danilovski, Aleksandar ; Dumbović, Alojz ; Zdravka, Knežević ; Lazarevski, Gorjana ; Filić, Darko ; Cinčić, Dominik ; Lazarić, Katica ; Bučar, Dejan Krešimir

Broj patenta
20040092460

Godina
2004

Datum patenta
13.05.2004.

Nositelj prava
DARBY & DARBY P.C., Zagreb, Hrvatska

Sažetak
Substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A. In addition, this disclosure is directed to a process for the preparation thereof from crude 9-deoxo-9a-aza-9a-methyl-9a-homoerythromyc- in A via orthorhombic isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A, of the general formula I 1 wherein S represents a water-miscible or water-immiscible organic solvent, characterized by the orthorhombic space group P2.sub.12.sub.12.sub.1, with average unit cell parameters a=8.2 to 9.7 .ANG., b=11.5 to 13.5 .ANG., c=44.5 to 47.0 .ANG., .alpha.=.beta.=.gamma.=90.degree., wherein a, b and c represent the crystal axes lengths and .alpha., .beta. and .gamma. represent the angles between the crystal axes. In addition, pharmaceutical compositions containing the substantially pure amorphous 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A are disclosed, as well as a method for the treatment of bacterial and protozoal infections, and inflammation related diseases in humans and animals by administration of a pharmaceutical composition containing same.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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