Naslov
Isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a- methyl-9a-homoerythrom- ycin A

Autori
Dumić, Miljenko ; Vinković, Mladen ; Orešić, Marina ; Meštrović, Ernest ; Danilovski, Aleksandar ; Dumbović, Alojz ; Knežević, Zdravka ; Lazarevski, Gorjana ; Cinčić, Dominik ; Filić, Darko ; Lazarić, Katica ; Bučar, Dejan Krešimir

Broj patenta
20040014951

Godina
2004

Datum patenta
22.01.2004.

Nositelj prava
DARBY & DARBY P.C., Zagreb, Hrvatska

Sažetak
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A having the Formula I: 1 wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, 0.5, or 1, the pseudopolymorph being characterized by the monoclinic space group P2.sub.1 and average unit cell parameters comprising: crystal axis lengths of a=15.5-17.0 .ANG., b=15.5-17.0 .ANG., and c=17.5-19.5 .ANG., and angles between the crystal axes of .alpha.=.gamma.=90.degree. and .beta.=106.degree.-112.deg- ree.. In addition, this disclosure is directed to processes for the preparation of the substantially pure isostructural pseudopolymorphs of Formula I ; to pharmaceutical compositions containing substantially pure isostructural pseudopolymorphs of Formula I ; and to a method for the treatment of bacterial and protozoan infections, and inflammation-related diseases by administration of a pharmaceutical composition containing the substantially pure isostructural pseudopolymorphs of Formula I.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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