Pregled bibliografske jedinice broj: 194418
Immunological characterisation of reverse transcriptases from human tumors: evidence for subgroup-specific interspecies antigenic determinants on the reverse transcriptase molecule
Immunological characterisation of reverse transcriptases from human tumors: evidence for subgroup-specific interspecies antigenic determinants on the reverse transcriptase molecule // Cold Spring Harbor Conferences on Cell Proliferation
Lahti: Cold Spring Harbor Laboratory (CSHL), 1980. str. 775-791 (pozvano predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 194418 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Immunological characterisation of reverse transcriptases from human tumors: evidence for subgroup-specific interspecies antigenic determinants on the reverse transcriptase molecule
Autori
Chandra, Prakash ; Steel, Linda, K. ; Laube, Horst ; Balikcioglu, Salim ; Mildner, Boris ; Ebener, Uwe ; Welte, Karl ; Vogel, Angelika
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Cold Spring Harbor Conferences on Cell Proliferation
/ - Lahti : Cold Spring Harbor Laboratory (CSHL), 1980, 775-791
Skup
Viruses in Naturally Occuring Cancers
Mjesto i datum
Cold Spring Harbor (NY), Sjedinjene Američke Države, 01.04.1980. - 05.04.1980
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
human tumors; reverse transcriptase (RT); immunological and biochemical characterization
Sažetak
We have reported the biochemical characteization and serological analysis of RTases from (1) a human spleen of a patient with myelofibrosis, (2) a granulocytic sarcoma associated with AMML in Turkish children, (3) a human primary melanoma tissue, and (4) a human osteosarcoma tissue. Except for minor differences, all these RTases closely resemble one another in their biochemical properties. However, on serological analysis, each of these enzymes showed a very characteristic pattern of antigenic nature. The enzymes from MFS, AML cells, and the AMML-associated orbital tumor seem to be closely related to the SiSV/GALV group of RTases, whereas the RTases from human melanoma tissue and osteosarcoma exhibited a different pattern of antigenic specificity. These RTases did not cross-react with antibodies to RTases from SiSV, GALV, and MFS. Both enzymes were strongly neutralized by antibodies to purified polymerases from BaEV and RD114, almost as effectivly as their homologous enzymes. Although in all the types of malignancies described above the involvement of type-C viruses has been implicated, their RTases exhibit different antigenic behaviors.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
