Naslov
Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats

Autori
Milin, Čedomila ; Radošević-Stašić, Biserka ; Kirigin, Mladena ; Hinić, Višnja ; Rukavina, Daniel ; Per-Olof Berggren ; Efendić, Suad

Izvornik
Bioscience reports (0144-8463) 11 (1991), 1; 1-6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
somatostatin; liver regeneration; phospholipids

Sažetak
Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked an increase in total lipids, and specially in phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS+PI fractions indicates a specific interference of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphadylinositol breakdown.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA