Naslov
The effects of somatostatin on stress-induced gastric lesion in mice

Autori
Senečić, I. ; Sikirić, Predrag ; Giljanović, Sanja ; Jagić, Vjekoslav ; Dodig, Milan ; Djermanović, Ž. ; Komerički, Ljiljana ; Banić, Marko ; Brkić, Tomislav ; Erceg, Damir ; Lučinger, Dražen ; Seiwerth, Sven ; Grabarević, Željko ; Rotkvić, Ivo ; Duvnjak, Marko ; Artuković, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the / - , 1990, 8-8

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Somatostatin; stress-induced; gastric lesions

Sažetak
It is in ganerally accepted that somatostatin has an important role in gastrointestinal tract. We investigated the influence of somatostatin on experimental gastric lesions in mice, since most result suggesting its protective effect were previously obtained in stressed rats. Lesions were induced as described before (Rasanen, Acta Physiolo. Scand., 58, 201, 1963). Somatostatin (0.01, 0.1, 1.0 mg/kg b.w.) was applied i.p. immediatly before stress procedure. Control mice recieved an equivolume of saline (4.0 ml/kg b.w.) i.p.. After scarificing, the gastric lesion were assessed as before (Sikirić et al., EJP 158, 61, 1988). In comparison to the control values, somatostatin does protect when is given 1.0, 0.1 mg/kg b.w.. In contrast, it demonstrated an opposite ulcerogenic effects when is given in the smallest dose (0.01 mg/kg b.w.). Conclusion: These results suggest that somatostatin has a dose-dependent, a probably not species related protective effect in stress. However, its aggravating effect needs further investigation.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

Napomena
Degestive Diseases and Sciences (0163-2116) 35 (1990) (8) 8-8

POVEZANOST RADA