Naslov
EUROCAT registration of congenital anomalies from 83 to 1993 in Croatia

Autori
Kapitanović, Helena ; Barišić, Ingeborg ; Ligutić, Ivo

Izvornik
Medizinische Genetik (0936-5931) 2 (1995);

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
EUROCAT; epidemiology; congenital anomalies; Croatia

Sažetak
Results of the eleven-years surveillance on congenital anomalies in four regions of Croatia (Varaždin, Koprivnica, Rijeka and Pula) are presented. This study was carried out as a part of EUROCAT (European Registration of Congenital anomalies) program. This project is based on a network of regional registries that cover geographically defined populations. All participating centers are coordinated by a central registry in Brussels. The statistical monitoring analysis included for each condition: a graphical display of prevalence rates, a Chi-square analysis, a Cusum analysis, a Scan analysis. During the 1983-1993 period 1228 cases with congenital anomalies were reported on 65 100 resident newborns. It yields the average prevalence rate of 18.86 per 1000 births. The most frequent selected malformations are: ventricular septal defect 115 (1.6/10 000 births), hypospadias 83 (12.7), Down's syndrome 76 (11.7), cleft lip &plusmn ; ; palate67 (10.2), atrial septal defect 51 (7.8), polydactyly 50 (7.7), microcephaly 33 (5.1), cleft palate 32 (4.9), hydrocephaly 31 (4.8), syndactyly 26 (3.9), spina bifida 20 (2.8), veiscourethral reflux (2.6), transposition of great arteries 18 (2.8), congenital hypertrophic pyloric stenosis 15 (2.3), cystic kidney 15 82.3), gastroschisis 13 (1.9), esophageal atresia with tracheo-esophageal fistula 12 (1.8), omphalocele 10 (1.5), hypoplastic left heart 10 (1.5). The statistical monitoring analysis performed on data in the monitored period shows a possible increase in prevalence rates of cleft lip &plusmn ; ; palate as well as an abnormal fluctuation in prevalence rates of Down's syndrome. Comparison of rates of Down’ s syndrome with other EUROCAT registries established an unusually high rate during the 1983-1993 period, that should be followed in future.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA