Naslov
The influence of unilateral or bilateral lesion of the nucleus basalis on the passive avoidance responses in rats

Autori
Župan, Gordana ; Simonić, Ante ; Krstulja, Mira

Izvornik
Iugoslavica physiologica et pharmacologica acta (0021-3225) 25 (1989); 161-162

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
nucleus basalis unilateral and bilateral lesions ; passive avoidance behavior ; rat

Sažetak
It was of interest to study the influence of unilateral or bilateral electrolytic lesions of the NB on the passive avoidance behaviour in rats. Anesthetized male Wistar rats weighing 200-250 g (4-5 months old) or 350-480 g (more than 1 year old) were placed in a stereotaxic apparatus. The coordinates for unilateral or bilateral NB lesions for older animals were: 1.8 mm anterior ; 2.5 mm lateral and 8.0 mm ventral with bregma as 0. For younger rats the used coordinates were: 0.7 mm posterior ; 2.7 mm lateral and 8.0 mm ventral with bregma as 0. In sham lesioned rats the electrode was lowered into the NB, but without turning on the current. Fifteen day later passive avoidance task was performed. At the end of experiment the site of the lesion was histologically verified. Our results show that both unilateral and bilateral electrolytic lesions of the NB impaired the passive avoidance responses in young and old rats. Bilateral in comparison with unilateral NB lesion produced significantly higher avoidance deficit. These results suggest that the NB cells intact activity is a prerequisite to unimpaired performance in learning and memory tasks in young and old rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA